Conjugation of benzoic acid in marsupials
نویسندگان
چکیده
منابع مشابه
The Conjugation of Benzoic Acid in Man*
The extensive investigations on the conjugation of benzoic acid, since Wohler’s discovery in 1824 of the synthesis of hippuric acid by the animal, have failed to furnish a comprehensive and definite concept of the metabolic and chemical changes taking place when benzoic acid is introduced into the organism. No attempt has ever been made to explain why man eliminates benzoic acid almost complete...
متن کاملOn the Chemistry of the Conjugation of Benzoic Acid*
In trying to find a reason why the dog excretes three-quarters of the ingested benzoic acid as glycuronic acid monobenzoate and only one-quarter as hippuric acid, the most satisfactory explanation seems to be found in the view that the processes of conjugation are chemical reactions, catalyzed by enzymes, and obeying the law of mass action. It should therefore be possible to study these mechani...
متن کاملThe Effect of Liver Injury on the Conjugation of Benzoic Acid in the Dog*
In a recent study (1) it was found that the synthesis of hippuric acid is markedly diminished in various diseases of the liver especially those in which jaundice is present. These results are all the more interesting because in spite of the extensive research that has been done on hippuric acid, little attention has hitherto been given to the effect of liver damage. The discovery of Bunge and S...
متن کاملEffects of fibrates on the glycine conjugation of benzoic acid in rats.
In the course of glycine conjugation, benzoic acid is successively converted into benzoyl-CoA and benzoylglycine by mitochondrial enzymes (i.e. benzoyl-CoA synthetase and benzoyl-CoA/glycine N-acyltransferase, respectively), utilizing ATP, CoA, and glycine. Large doses of benzoate deplete CoA from the liver, suggesting that the supply of CoA may limit the capacity for glycine conjugation. Becau...
متن کاملThe conjugation of phenol, benzoic acid, 1-naphthylacetic acid and sulphadimethoxine in the lion, civet and genet.
In the domestic cat (FeZis catus) phenol is converted mainly to phenylsulphate with only small amounts of phenylglucuronide [l] . The cat’s ability to form the glucuronides of foreign compounds is low compared with other species [2] and it forms little or no glucuronide with phenol [I], benzoic acid [3], sulphadimethoxine [4] , or 1-naphthylacetic acid [5]. It was of interest therefore to find ...
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ژورنال
عنوان ژورنال: Australian Journal of Zoology
سال: 1985
ISSN: 0004-959X
DOI: 10.1071/zo9850693